Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)*
Identifieur interne : 001257 ( Main/Exploration ); précédent : 001256; suivant : 001258Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)*
Auteurs : P. Schuff Erner ; E. Schütz ; W. C. Seyde [Allemagne] ; Th. Eisenhauer ; G. Janning ; V. W. Armstrong ; D. SeidelSource :
- European Journal of Clinical Investigation [ 0014-2972 ] ; 1989-10.
English descriptors
- KwdEn :
Abstract
Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range < 5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30±4 to 37±7 mmHg and from 27±2 to 31±3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.
Url:
DOI: 10.1111/j.1365-2362.1989.tb00303.x
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)*</title><author><name sortKey="Schuff Erner, P" sort="Schuff Erner, P" uniqKey="Schuff Erner P" first="P." last="Schuff Erner">P. Schuff Erner</name></author><author><name sortKey="Schutz, E" sort="Schutz, E" uniqKey="Schutz E" first="E." last="Schütz">E. Schütz</name></author><author><name sortKey="Seyde, W C" sort="Seyde, W C" uniqKey="Seyde W" first="W. C." last="Seyde">W. C. Seyde</name></author><author><name sortKey="Eisenhauer, Th" sort="Eisenhauer, Th" uniqKey="Eisenhauer T" first="Th." last="Eisenhauer">Th. Eisenhauer</name></author><author><name sortKey="Janning, G" sort="Janning, G" uniqKey="Janning G" first="G." last="Janning">G. Janning</name></author><author><name sortKey="Armstrong, V W" sort="Armstrong, V W" uniqKey="Armstrong V" first="V. W." last="Armstrong">V. W. Armstrong</name></author><author><name sortKey="Seidel, D" sort="Seidel, D" uniqKey="Seidel D" first="D." last="Seidel">D. Seidel</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D490A7EA157432683BDD8078FCAFF7C0E219F4EE</idno><date when="1989" year="1989">1989</date><idno type="doi">10.1111/j.1365-2362.1989.tb00303.x</idno><idno type="url">https://api.istex.fr/document/D490A7EA157432683BDD8078FCAFF7C0E219F4EE/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000D94</idno><idno type="wicri:Area/Main/Curation">000D72</idno><idno type="wicri:Area/Main/Exploration">001257</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">001257</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)*</title><author><name sortKey="Schuff Erner, P" sort="Schuff Erner, P" uniqKey="Schuff Erner P" first="P." last="Schuff Erner">P. Schuff Erner</name><affiliation><wicri:noCountry code="no comma">†Department of Clinical Chemistry</wicri:noCountry></affiliation></author><author><name sortKey="Schutz, E" sort="Schutz, E" uniqKey="Schutz E" first="E." last="Schütz">E. Schütz</name><affiliation><wicri:noCountry code="no comma">†Department of Clinical Chemistry</wicri:noCountry></affiliation></author><author><name sortKey="Seyde, W C" sort="Seyde, W C" uniqKey="Seyde W" first="W. C." last="Seyde">W. C. Seyde</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>‡Department of Anesthesiology, University Clinics, Robert‐Koch‐Strasse 40, D‐3400 Goettingen</wicri:regionArea><wicri:noRegion>D‐3400 Goettingen</wicri:noRegion><wicri:noRegion>D‐3400 Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Eisenhauer, Th" sort="Eisenhauer, Th" uniqKey="Eisenhauer T" first="Th." last="Eisenhauer">Th. Eisenhauer</name><affiliation><wicri:noCountry code="no comma">§Department of Nephrology and Rheumatology</wicri:noCountry></affiliation></author><author><name sortKey="Janning, G" sort="Janning, G" uniqKey="Janning G" first="G." last="Janning">G. Janning</name><affiliation><wicri:noCountry code="no comma">§Department of Nephrology and Rheumatology</wicri:noCountry></affiliation></author><author><name sortKey="Armstrong, V W" sort="Armstrong, V W" uniqKey="Armstrong V" first="V. W." last="Armstrong">V. W. Armstrong</name><affiliation><wicri:noCountry code="no comma">†Department of Clinical Chemistry</wicri:noCountry></affiliation></author><author><name sortKey="Seidel, D" sort="Seidel, D" uniqKey="Seidel D" first="D." last="Seidel">D. Seidel</name><affiliation><wicri:noCountry code="no comma">†Department of Clinical Chemistry</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Clinical Investigation</title><idno type="ISSN">0014-2972</idno><idno type="eISSN">1365-2362</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-10">1989-10</date><biblScope unit="volume">19</biblScope><biblScope unit="supplement">s1</biblScope><biblScope unit="page" from="30">30</biblScope><biblScope unit="page" to="37">37</biblScope></imprint><idno type="ISSN">0014-2972</idno></series><idno type="istex">D490A7EA157432683BDD8078FCAFF7C0E219F4EE</idno><idno type="DOI">10.1111/j.1365-2362.1989.tb00303.x</idno><idno type="ArticleID">ECI30</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2972</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Atherosclerosis</term><term>LDL‐cholesterol</term><term>blood fluidity</term><term>erythrocyte aggregation</term><term>haemorheology</term><term>heparin‐induced‐LDL‐apheresis</term><term>plasma viscosity</term><term>tissue oxygen tension</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract. Heparin‐induced Extracorporeal LDL‐Pre‐cipitation (HELP) is an effective procedure for the elimination of both plasma LDL and fibrinogen. In 10 adult patients with severe type II hyperlipoproteinemia, a single HELP treatment of 3 1 plasma led to an acute decrease in the average plasma viscosity (PV) from 1.30 to 1.1 mPas. At the same time, an even more marked decrease in the mean erythrocyte aggregation rate from a pathological value of 7.9% to a value of 3.7% (normal range < 5%) was observed. Long‐term studies on five patients demonstrated a lasting improvement in these two haemorheological variables. The acute rheological changes were also accompanied by an improvement in polarographically determined muscle oxygen tension. Mean oxygen tension values measured in both the m.biceps brachii and the m.tibia‐lis anterior in five patients before and after a single HELP treatment increased from 30±4 to 37±7 mmHg and from 27±2 to 31±3 mmHg respectively. These results may provide an explanation for the rapid improvement in patients' clinical symptoms such as angina pectoris and in stress electrocardiogram which have been observed during HELP therapy.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Armstrong, V W" sort="Armstrong, V W" uniqKey="Armstrong V" first="V. W." last="Armstrong">V. W. Armstrong</name><name sortKey="Eisenhauer, Th" sort="Eisenhauer, Th" uniqKey="Eisenhauer T" first="Th." last="Eisenhauer">Th. Eisenhauer</name><name sortKey="Janning, G" sort="Janning, G" uniqKey="Janning G" first="G." last="Janning">G. Janning</name><name sortKey="Schuff Erner, P" sort="Schuff Erner, P" uniqKey="Schuff Erner P" first="P." last="Schuff Erner">P. Schuff Erner</name><name sortKey="Schutz, E" sort="Schutz, E" uniqKey="Schutz E" first="E." last="Schütz">E. Schütz</name><name sortKey="Seidel, D" sort="Seidel, D" uniqKey="Seidel D" first="D." last="Seidel">D. Seidel</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Seyde, W C" sort="Seyde, W C" uniqKey="Seyde W" first="W. C." last="Seyde">W. C. Seyde</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001257 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001257 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= SchutzV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D490A7EA157432683BDD8078FCAFF7C0E219F4EE
|texte= Improved haemorheology associated with a reduction in plasma fibrinogen and LDL in patients being treated by heparin‐induced extracorporeal LDL precipitation (HELP)*
}}
| This area was generated with Dilib version V0.6.38. |  |